ea0012p92 | Reproduction | SFE2006
Appleby GF
, Thompson EL
, Murphy KG
, Patterson M
, Bewick GA
, Stamp GWH
, Todd JF
, Ghatei MA
, Bloom SR
Kisspeptin-54 is a neuropeptide encoded by the Kiss-1 gene with an important role in the regulation of reproduction and puberty. Acute peripheral or intra-hypothalamic administration of kisspeptin-54 potently stimulates the hypothalamo-pituitary-gonadal (HPG) axis via hypothalamic gonadotrophin releasing hormone (GnRH) neurons. However, the effects of chronic continuous kisspeptin administration are poorly characterised. Our studies investigated the effects of chronic, continu...